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Boochawan

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Posts posted by Boochawan

  2. Driving Under Influence of Marijuana

    in Soundboard

    Posted

    I find it incredibly odd that the prosecution didn't question H under oath to whether or not he ingested marijuana (or a THC containing compound). The attending physician and the lawyers need to brush up on their pharmokinetics...the rate of onset is much slower via the oral route of administration than of smoking - that's their evidence right there to why his THC levels were so high 2 hours after the accident

  13. Vanderpark - Feb24(Toronto) Feb25(Hamilton)

    in Soundboard

    Posted

    Hey all - we're playing a couple shows this week, with stops in T.O and our first stop in Steeltown.

    Here she goes:

    Thursday, Feb 24, 2005

    The 360 :: 326 Queen St. W :: Toronto, ON

    $6 Cover :: Doors @ 9pm

    w/ Constants (from Boston) plus Sushi Boy and Dagger

    Friday, Feb 25, 2005

    Pepperjacks Cafe :: 38 King Williams St. :: Hamilton, ON

    $6 Cover :: Doors @ 9pm

    w/ Mark Wilson and The Way It Is and The Earthtones

    Peace!

    Booch ::

  14. US Troops given E to cope

    in Soundboard

    Posted

    Boochawan, what's your definition of "keeping them on E"? Is once or twice a month "ON" a drug? curious.....

    Deb,

    When a subject in an experiment is put on protocol, there are risks and benefits that are evaluated prior to the implementation of that protocol. When a drug trial is taking place, part of this risk/benefit analysis takes the pharmacodynamic nature of the drug being studied. Just like most substances (caffeine, nicotine, etc), one can develop tolerance (in this case an acute tolerance) if taken over a short period of time on a regular basis. The abuse liability (the likelyhood of the drug being abused due to its positive rewarding effect) of MDMA is extremely high, because of the increased amount of Serotonin (the 'happy' chemical) in the synapses. MDMA encourages this infusion, and once drugs half life (amount of time drug is in the body) expires, one goes through withdrawal. For instance, if one does half a tab of E and comes down faster, one may take more E to eliminate the withdrawal. If these subjects in this experiment are given E on a regular basis to help with their emotional expression, what do the researchers plan on doing once the study is over? If the researchers stopped giving them the drug right after the study (cold turkey) the withdrawal effects of MDMA (anxiety, depression, increased heart rate and blood pressure, etc) can be detrimental, let alone cause a re-currence of their symptoms of PTSD...and due to the pharmacokinetic nature of MDMA (which i'll spare at this moment) their symptoms could be even worse. I don't know what the researchers will do (whether it'll be once or twice a month, it depends on the dose) but they will have to keep the subjects on, or at least attempt to ween them off the drug, with various amounts of drug in their system because they would have reached a steady-state of the drug in their blood at this point. It's more a matter of ethics then anything else.

    However, another ethical concern is the fact that there is such a high abuse liability. Is it ethical to potentially get someone addicted to the drug? That's what I'm interested in and on what grounds the ethical review board approved this study. I know it's a long response, but i hope it answers your question.

  15. US Troops given E to cope

    in Soundboard

    Posted

    Wow.

    MDMA was used briefly in the '70s as a therapeutic tool (similar to what they are trying to accomplish here) and was discontinued because of the obvious abuse potential of the drug. This is interesting that it is being brought back for a clinical trial...

    Though MDMA can evoke empathy, the side effets and withdrawal effects can induce possible depression and anxiety, which would, in effect, worsen their orignal diagnosis of PTSD. I wonder what the researchers plan on doing once the clinical trial is over - to prevent symptoms from re-occuring...i wonder if they will have to keep them on E?

  17. "Wow, that's hot"

    in Soundboard

    Posted

    yes, i'll second (or third?) that.

    But it just goes to show you, that this phrase can garnish all these hits and create a lengthy thread, no matter how many people complain about it - point being, we're all immersed in pop culture whether we'd like to admit it or not.

  25. UPCOMING PJC SHOWS...

    in Soundboard

    Posted

    Saturday, Mar. 12th: KOBAYASHI , THE QUARTERTONES (feat. serious )

    This will be a wicked show - Kobayashi was one of the first bands I was introduced to when I moved to montreal a few years back and still one of my favorite local acts. Killer grooves, singing, you name it. They do a wicked cover of Gillespie's "Night in Tunisia" - which, coincidently, is what got me hooked on the band.

    And Lazlo - as far as I know we're playing PJC on Friday the 25th, not the 26th.

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